Development of a production scale purification of Ge-68 from irradiated gallium metal

Autor:	Jonathan Fitzsimmons, Leonard F. Mausner
Rok vydání:	2014
Předmět:	Metal chemistry visual_art Radiochemistry visual_art.visual_art_medium chemistry.chemical_element Irradiation Physical and Theoretical Chemistry Gallium Nuclear chemistry
Zdroj:	Radiochimica Acta. 103:117-123
ISSN:	2193-3405 0033-8230
Popis:	Germanium-68 (Ge-68) is produced by proton irradiation of a gallium metal target and purified by organic extraction. The Ge-68 can be used in a medical isotope generator to produce Gallium-68 (Ga-68) which can be used to radiolabel PET imaging agents. The emerging use of Ge-68 in the Ga-68 medical isotope generator has caused us to develop a new purification method for Ge-68 that does not use toxic solvents. The purpose of this work was to develop a production scale separation of Ge-68 that utilizes a leaching step to remove a bulk of the gallium metal, followed by purification with Sephadex© G25. Production scale (300 mCi) purification was performed with the new method. The purified Ge-68 contained the highest radioactivity concentration of Ge-68 produced at BNL; the sample meet Department of Energy specifications and the method had an excellent recovery of Ge-68.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::de4cf9514c5983d78938d018374beea4 https://doi.org/10.1515/ract-2014-2306 Zobrazit plný text záznamu