Autor: S. R. Rannels, L. M. Brown, Danny R. Welch
Rok vydání: 2002
Předmět:
Zdroj: Clinical and Experimental Metastasis. 19:369-376
ISSN: 0262-0898
DOI: 10.1023/a:1016345627965
Popis: Surgical resection of lung tissue is employed clinically as a therapy for pulmonary metastases; however, local cancer recurrence is a frequent post-surgical complication. In a variety of small mammals, left pneumonectomy (PNX) initiates rapid compensatory hyperplasia of the remnant lung lobes restoring normal tissue mass, structure and function. Post-PNX compensatory lung growth is known to promote lung tumor formation in carcinogen-treated mice. The present study tests the hypothesis that PNX enhances experimental metastasis to lung. C57Bl/6 mice subjected to PNX were given an intravenous injection of B16F10 melanoma cells at various stages of compensatory lung growth. Animals injected with B16F10 cells during the linear phase of the response had 77% to 260% more pulmonary metastases than mice subjected to thoracotomy (P
Databáze: OpenAIRE
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