The Malaria Cell Atlas: a comprehensive reference of single parasite transcriptomes across the complete Plasmodium life cycle
| Autor: | Haynes Heaton, Kedar Nath Natarajan, Adam J. Reid, Virginia M. Howick, Lisa H. Verzier, Arthur M. Talman, Julian C. Rayner, Mara K. N. Lawniczak, Matthew Berriman, Martin Hemberg, Hellen Butungi, Andrew Russell, Oliver Billker, Jeremy K. Herren, Tom Metcalf, Tallulah S. Andrews |
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| Rok vydání: | 2019 |
| Předmět: |
030213 general clinical medicine
0303 health sciences Cell Biology medicine.disease biology.organism_classification Life stage 3. Good health Transcriptome 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Evolutionary biology parasitic diseases medicine Parasite hosting Plasmodium berghei Gene Malaria 030304 developmental biology |
| DOI: | 10.1101/527556 |
| Popis: | Malaria parasites adopt a remarkable variety of morphological life stages as they transition through multiple mammalian host and mosquito vector environments. Here we profile the single-cell transcriptomes of thousands of individual parasites, deriving the first high-resolution transcriptional atlas of the entire Plasmodium berghei life cycle. We then use our atlas to precisely define developmental stages of single cells from three different human malaria parasite species, including parasites isolated directly from infected individuals. The Malaria Cell Atlas provides both a comprehensive view of gene usage in a complex eukaryotic parasite and an open access reference data set for the study of malaria parasites. |
| Databáze: | OpenAIRE |
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