Dual isotopes imaging in whole-body autoradiography (WBARG): distribution of 14C-benzo-a-pyrene and 113Sn-tributyltin in mummichog (Fundulus heteroclitus)
| Autor: | Claude Rouleau, E. Pelletier, Isabelle Desbiens, Ciro Alberto Oliveira Ribeiro, Heloísa H.P. Oliveira |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Health Toxicology and Mutagenesis medicine.medical_treatment Intraperitoneal injection 010501 environmental sciences 01 natural sciences Analytical Chemistry 03 medical and health sciences chemistry.chemical_compound medicine Distribution (pharmacology) Radiology Nuclear Medicine and imaging Spectroscopy 0105 earth and related environmental sciences biology Isotope Radiochemistry Public Health Environmental and Occupational Health biology.organism_classification Pollution Fundulus Mummichog 030104 developmental biology Nuclear Energy and Engineering Benzo(a)pyrene chemistry Environmental chemistry Tributyltin Whole body |
| Zdroj: | Journal of Radioanalytical and Nuclear Chemistry. 307:917-929 |
| ISSN: | 1588-2780 0236-5731 |
| DOI: | 10.1007/s10967-015-4545-z |
| Popis: | Tissue distributions of 14C-BaP and 113Sn-TBT, individually and together, were compared in mummichog by WBARG, after forced-feeding or intraperitoneal injection. Electron differential absorption (EDA) by metal foil was tested to visualize the distribution of 14C and 113Sn in tissue sections of animals exposed to both radiochemicals. Distribution of 14C and 113Sn in fish did not differ as a function of exposure route, but 14C liver/blood and bile/blood concentration ratios were lower in fish dosed with BaP + TBT. EDA allowed a clear differentiation of 14C and 113Sn signals and could be used to image other radionuclides pairs. |
| Databáze: | OpenAIRE |
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