A New Aspect of Cholinergic Transmission in the Central Nervous System
| Autor: | Takanobu Taniguchi, Hatsumi Yoshiki, Kung-Shing Lee, Junsuke Uwada, Takayoshi Masuoka, Takashi Yazama, Kiyonao Sada, Takaharu Ishibashi, Matomo Nishio, Ikunobu Muramatsu |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Acetylcholine uptake Central nervous system 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure chemistry Postsynaptic potential medicine Cholinergic Cholinergic synapse Neurotransmitter Neuroscience 030217 neurology & neurosurgery Acetylcholine medicine.drug Acetylcholine receptor |
| Zdroj: | Nicotinic Acetylcholine Receptor Signaling in Neuroprotection ISBN: 9789811084874 |
| DOI: | 10.1007/978-981-10-8488-1_3 |
| Popis: | In the central nervous system, acetylcholine (ACh) is an important neurotransmitter related to higher brain functions and some neurodegenerative diseases. It is released from cholinergic nerve terminals and acts on presynaptic and postsynaptic ACh receptors (AChRs). Following release, ACh is rapidly hydrolyzed and the resultant choline is recycled as a substrate for new ACh synthesis. However, this classical concept of cholinergic transmission is currently reevaluated due to new evidence. In the cholinergic synapse, ACh may be itself taken up into postsynaptic neurons by a specific transport system and may act on AChRs at intracellular organelles (Golgi apparatus and mitochondria). Choline for ACh synthesis in cholinergic nerve terminals may be mainly supplied from choline at relevant concentration levels present in the extracellular space, rather than recycled from ACh-derived choline. Recent evidence has reopened the issue of classical cholinergic transmission and cognition, and may provide a novel approach to rational drug development for the treatment of neurodegenerative disorders such as Alzheimer’s disease. |
| Databáze: | OpenAIRE |
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