| Autor: |
S.W. de Laat, E.J.J. van Zoelen, T. M. J. Van Oostwaard |
| Rok vydání: |
1989 |
| Předmět: |
|
| Zdroj: |
Cell to Cell Signals in Mammalian Development ISBN: 9783642731440 |
| DOI: |
10.1007/978-3-642-73142-6_22 |
| Popis: |
Using growth factors-defined and serum—free culture media, we have shown that phenotypic transformation of normal rat kidney cells does not require specific polypeptide growth factors but more generally reflects the ability of these cells to respond to multiple growth factors. Epidermal growth factor and platelet-derived growth factor contribute to this process by a direct mitogenic action on these cells, modulating agents like transforming growth factor—β and retinoic acid have an indirect growth stimulating effect. Some aspects of the mechanism whereby these modulating agents can exert their action will be discussed. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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