Protective properties of the receptor domain of anthrax exotoxin protective antigen depend from the orientation of its presentation on nanoparticles

Autor:	O. D. Sklyarov, O. N. Shcheglovitova, K. A. Noskov, A. N. Noskov
Rok vydání:	2011
Předmět:	biology Chemistry Organic Chemistry Antigen presentation medicine.disease_cause Biochemistry Molecular biology law.invention Protein structure Antigen In vivo law Recombinant DNA Biophysics biology.protein medicine Antibody Receptor Exotoxin
Zdroj:	Russian Journal of Bioorganic Chemistry. 37:448-452
ISSN:	1608-330X 1068-1620
DOI:	10.1134/s106816201104008x
Popis:	Polystyrene nanoparticles carrying on their surface recombinant proteins of the receptor domain of anthrax exotoxin protective antigen presented in different orientations were constructed. In vivo testing demonstrated that the particles with an exposed COOH region of the receptor domain displayed the highest protective properties (95%) in a mouse anthrax model. It was shown that immunization with such particles induced a specific Th1 response with increased levels of the cytokines TNF-α and IL-2.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::de2785e0f03ad336a9651bf15244e391 https://doi.org/10.1134/s106816201104008x Zobrazit plný text záznamu Full text from SpringerLink