New diterpene alkaloids from the marine sponge Agelas mauritiana
| Autor: | Hou-Wen Lin, Man Liu, Jie Tang, Wei Zhang, Fan Sun, Wei-Hua Jiao, Jia-Bao Sun, Li-Li Hong, Fan Yang, Shu-Ping Wang |
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| Rok vydání: | 2017 |
| Předmět: |
biology
010405 organic chemistry Stereochemistry General Chemical Engineering General Chemistry Agelasine biology.organism_classification medicine.disease_cause 01 natural sciences 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Sponge Agelas mauritiana chemistry Staphylococcus aureus Ic50 values medicine Diterpene Cancer cell lines Cytotoxicity |
| Zdroj: | RSC Adv.. 7:23970-23976 |
| ISSN: | 2046-2069 |
| DOI: | 10.1039/c7ra02547e |
| Popis: | Chemical investigation of an ethanol extract of the sponge Agelas mauritiana led to the isolation and characterization of five new diterpene alkaloids, namely, (−)-8′-oxo-agelasine B (1), (+)-agelasine B (2), (+)-8′-oxo-agelasine C (3), agelasine V (4), and (+)-8′-oxo-agelasine E (5), along with two known compounds, (−)-8′-oxo-agelasine D (6), and agelasine D (7). The structures of these compounds were determined by interpretation of spectroscopic data and comparison with literature properties. Compounds 1 and 3–5 are the second example of 8′-oxo-agelasine analogs. Compounds 2 and 7 not only exhibited moderate cytotoxicity toward the cancer cell lines PC9, A549, HepG2, MCF-7, and U937 with IC50 values of 4.49–14.41 μM, but also showed potent antibacterial activities against a panel of methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates with MIC90 values of 1–8 μg mL−1. |
| Databáze: | OpenAIRE |
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