| Popis: |
We have previously isolated the efp (estrogenresponsivefinger protein) that is required for the normalestrogen-induced cell proliferation. Here, we show the genomicorganization of the human efp gene which consists of nine exons.The efp mRNA was expressed in human breast tumors and theestrogen-induced expression of the efp was found in MCF-7human breast cancer cells. Moreover, efp promoter activity wasenhanced through the estrogen-responsive element dependent onestrogen and estrogen receptor. These results suggest that the efpcan mediate estrogen actions such as cell growth in human breastcancer as a primary responsive gene. |
