Chiral Calix[4]arene‐Based Diphosphites as Ligands in the Asymmetric Hydrogenation of Prochiral Olefins

Autor:	Angelica Marson, Piet W. N. M. van Leeuwen, Zoraida Freixa, Paul C. J. Kamer
Rok vydání:	2007
Předmět:	Inorganic Chemistry Chemistry Stereochemistry Calixarene Asymmetric hydrogenation Homogeneous catalysis Enantiomer Medicinal chemistry
Zdroj:	European Journal of Inorganic Chemistry. 2007:4587-4591
ISSN:	1099-0682 1434-1948
DOI:	10.1002/ejic.200700764
Popis:	Chiral calixarene-based diphosphite ligands 3a–d have been obtained via lower-rim functionalisation of the p-tert-butylcalix[4]arene core. High enantiomeric excesses (up to 94 %) and good activities were obtained in the rhodium-catalyzed asymmetric hydrogenation of prochiral olefins withTADDOL-containing diphosphites 3c,d. This is the firstexample of chiral calix[4]arene-modified ligands that induce high enantioselectivity in metal-catalysed asymmetric reactions.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Databáze:	OpenAIRE
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