Preparation of polymeric composition of linezolid and study of its antimicrobial activity in vitro
| Autor: | E. A. Vorontcov, V. V. Zavarzina, S. E. Severin, A. A. Novikova, E. S. Severin |
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| Rok vydání: | 2014 |
| Předmět: |
Active ingredient
chemistry.chemical_classification Materials science technology industry and agriculture General Engineering macromolecular substances Polymer Condensed Matter Physics medicine.disease_cause Antimicrobial chemistry.chemical_compound PLGA chemistry Staphylococcus aureus Linezolid medicine Organic chemistry General Materials Science Specific activity Particle size Nuclear chemistry |
| Zdroj: | Nanotechnologies in Russia. 9:453-456 |
| ISSN: | 1995-0799 1995-0780 |
| Popis: | This study focuses on the development of the polymeric composition of linezolid based on biodegradable polymeric carriers. Polymeric compositions within linezolid were prepared by the simple emulsification method using a series of polymers such as PLGA 50/50, PLGA 75/25, PLGA-COOH 50/50, Eudragit RL, and Eudragit RS. The best characteristics were achieved by a composition obtained by using the polymer PLGA 50/50. The content of linezolid in the composition was 9.4 ± 0.47%, the inclusion efficiency was 50 ± 2.50%, and the particle size was 275 ± 13 nm. A study of antimicrobial activity of the polymer composition was performed by standard methods using cambric tests on Myulton-Hiller medium at a concentration of active ingredient 500 μg/mL. Experimental results demonstrated that the polymeric composition exhibited higher specific activity against Staphylococcus aureus than the substance. |
| Databáze: | OpenAIRE |
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