Anterior cingulate cortex neuro-metabolic changes underlying lithium-induced euthymia in bipolar depression: A longitudinal 1H-MRS study
Autor: | Claudia da Costa Leite, Márcio Gerhardt Soeiro-de-Souza, E. Scotti-Muzzi, Fernando Fernandes, Rodrigo Machado-Vieira, R. T. De Sousa, Maria Concepcion Garcia Otaduy |
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Rok vydání: | 2021 |
Předmět: |
medicine.medical_specialty
Lithium (medication) 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Imaging Tool Internal medicine medicine Choline Pharmacology (medical) Bipolar disorder Biological Psychiatry Depression (differential diagnoses) Anterior cingulate cortex Pharmacology business.industry medicine.disease Proton magnetic resonance 030227 psychiatry Psychiatry and Mental health Endocrinology Mood medicine.anatomical_structure Neurology chemistry Neurology (clinical) business 030217 neurology & neurosurgery medicine.drug |
Zdroj: | European Neuropsychopharmacology. 49:93-100 |
ISSN: | 0924-977X |
Popis: | The diagnosis and treatment of bipolar depression (BDep) poses complex clinical challenges for psychiatry. Proton magnetic resonance spectroscopy (1H-MRS) is a useful imaging tool for investigating in vivo levels of brain neuro-metabolites, critical to understanding the process of mood dysregulation in Bipolar Disorder. Few studies have evaluated longitudinal clinical outcomes in BDep associated with 1H-MRS metabolic changes. This study aimed to longitudinally assess brain 1H-MRS metabolites in the anterior cingulate cortex (ACC) correlated with improvement in depression (from BDep to euthymia) after lithium treatment in BDep patients versus matched healthy controls (HC). Twenty-eight medication-free BDep patients and 28 HC, matched for age and gender, were included in this study. All subjects were submitted to a 3-Tesla brain 1H-MRS scan in the ACC using a single-voxel (8cm3) PRESS sequence at baseline. At follow-up (6 weeks), 14 BDep patients repeated the exam in euthymia. Patients with current BDep had higher baseline Myo-inositol/Cr (mI/Cr) and Choline/Cr (Cho/Cr) compared to HC. After six weeks, mI/Cr or Cho/Cr levels in subjects that achieved euthymia no longer differed to levels in HC, while high Cho/Cr levels persisted in non-responders . Elevated ACC mI/Cr and Cho/Cr in BDep might indicate increased abnormal membrane phospholipid metabolism and phosphatidylinositol (PI) cycle activity. Return of mI/Cr and Cho/Cr to normal levels after lithium-induced euthymia suggests a critical regulatory effect of lithium targeting the PI cycle involved in mood regulation. |
Databáze: | OpenAIRE |
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