Autor: Robert Lalonde, Pierre Chapillon, Catherine Belzung
Rok vydání: 2001
Předmět:
Zdroj: Behavior Genetics. 31:151-155
ISSN: 0001-8244
DOI: 10.1023/a:1010269126295
Popis: The Lurcher mutation is characterized by degeneration of the cerebellar cortex and cerebellar ataxia. The mutants were compared to littermate controls of the same background strain in three spatial tasks: 1) left-right discrimination in a water-filled T-maze, a reference memory task requiring a win-stay strategy; 2) the radial arm maze, a working memory task requiring a win-shift strategy; 3) object localization, a reference memory task requiring the use of cognitive mapping. Lurcher mutants were impaired in the object localization and radial arm maze tasks but not in the left-right discrimination task. These results indicate that trial-independent tasks and reference memory tasks using cognitive mapping may be particularly vulnerable to cerebellar degeneration.
Databáze: OpenAIRE