Solid phase chemistry approach to the SAR development of a novel class of active site-directed thrombin inhibitors

Autor:	Jan E. Gillespie, Robert J. Foglesong, Catherine C. Redick, Donetta S. Gifford-Moore, Gerald F. Smith, Daniel Jon Sall, Michael P. Lynch, Mary George Johnson, Jefferson Ray Mccowan, Kyomi Kalter, Duane D. Bronson
Rok vydání:	1999
Předmět:	Future studies biology Chemistry Organic Chemistry Amine functionalization Active site Benzothiophene Biochemistry Combinatorial chemistry chemistry.chemical_compound Phase (matter) Drug Discovery biology.protein Molecule Discovery and development of direct thrombin inhibitors
Zdroj:	Tetrahedron. 55:11641-11652
ISSN:	0040-4020
DOI:	10.1016/s0040-4020(99)00684-5
Popis:	A solid phase chemistry approach utilizing Mitsunobu chemistry, amine functionalization, and parallel purification was used to produce a diverse library of benzothiophene analogs. These analogs were used to advance the SAR of this class of molecules and give new directions for future studies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::de07f03f7797de0d91312b4c62d501f6 https://doi.org/10.1016/s0040-4020(99)00684-5 Zobrazit plný text záznamu Full Text from ScienceDirect