Late Breaking Abstract - Do the 2012 GLI multi-ethnic reference equations show a good fit for healthy black South Africans?
| Autor: | Sara-Jane Smith, Lindsay Zurba, Reratilwe Mphahlele, Sanja Stanojevic, Graham L. Hall, Diane Gray, Refiloe Masekela |
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| Rok vydání: | 2018 |
| Předmět: |
Spirometry
medicine.diagnostic_test business.industry Ethnic group respiratory system 010501 environmental sciences Southeast asian 01 natural sciences respiratory tract diseases 03 medical and health sciences FEV1/FVC ratio 0302 clinical medicine Lung disease Healthy individuals medicine 030212 general & internal medicine business Lung function 0105 earth and related environmental sciences Demography |
| Zdroj: | Respiratory function technologists/scient. |
| DOI: | 10.1183/13993003.congress-2018.oa3773 |
| Popis: | Introduction: Spirometry is critical for the management and diagnosis of lung disease. Interpretation relies on ethnically appropriate reference equations. The Global Lung Function Initiative spirometry equations (GLI2012) provide reference data for: Caucasian, Black, Southeast Asian, Northeast Asian, and Other. Aims and objectives: The GLI2012 ‘Black’ equation was derived from African-American data and we hypothesised that this may not be valid in black South Africans. Methods: Spirometry in healthy individuals aged 5-95 years in KwaZulu-Natal, South Africa was obtained. The validity of the GLI2012 ‘Black’, ‘Caucasian’ and ‘Other’ equations to contemporary healthy black South Africans was assessed with an a priori difference of 0.5 z-scores being defined as a difference of clinical and physiological relevance. Results: A total of 2691 participants were screened with 2329 in the final analysis after exclusion. Of these 1264 (54%) were of black South African ethnicity aged 5 to 87 years with 63% females. 42% lived in rural areas. The GLI2012 ‘Other’ equations provided the best fit with z-scores ±SD of (0.01 ± 1.16), (-0.03 ± 1.20) and (0.04 ± 0.86) for FEV1, FVC and FEV1/FVC respectively. In comparison, the GLI2012 ‘Black’ equation [(0.64 ±1.16), (0.57 ±1.13) and (0.10 ±0.82) for FEV1, FVC and FEV1/FVC, respectively] and the GLI2012 ‘Caucasian’ equation [(-0.56 ±1.08), (-0.67 ±1.06) and (0.19 ±0.81) for FEV1, FVC and FEV1/FVC respectively] demonstrated poor fit to contemporary, healthy black South Africans. Conclusion: The GLI2012 ‘Other’ spirometry reference equations provide a good fit to black South Africans. |
| Databáze: | OpenAIRE |
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