[Retracted] Synthetic miR‑145 mimic inhibits multiple myeloma cell growth in vitro and in vivo
| Autor: | Qi Zhang, Weiqun Yan, Hao Xu, Yang Bai, Jie Ma, Yingqiao Zhu, Changhao Fu, Wenwen Zheng |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Oncology Reports. 46 |
| ISSN: | 1791-2431 1021-335X |
| DOI: | 10.3892/or.2021.8125 |
| Popis: | Multiple myeloma (MM) is a disease with an adverse outcome and new therapeutic strategies are required to combat this disease. It is well known that tumor‑suppressor microRNA (miRNA) acts as a new potential anticancer agent. Accumulating evidence showed that microRNA-145 (miR-145) is a candidate tumor suppressor miRNA. However, whether miR-145 is involved in the development and progression of MM reamins to be determined. In the present study, we investigated the therapeutic potential of synthetic miR-145 against human MM cells in vitro and in vivo. The results showed that miR-145 was reduced in MM tissues and cell lines. Enforced expression of miR-145 by transfection with miR-145 mimics inhibited cell proliferation, migration, and the invasion abilities of H929 cells. Furthermore, our results demonstrated that the enforced expression of miR-145 in H929 cells profoundly decreased the levels of p-AKT and p-PI3K, which may contribute to some extent to the inhibition of MM cell proliferation and survival. The enforced expression of miR-145 in a xenograft mouse model suppressed tumor growth. In conclusion, our findings suggested that miR-145 may act as a tumor suppressor and contributes to the progression of MM. Additionally, miR-145 mimics is a potential therapeutic agent for the treatment of MM. |
| Databáze: | OpenAIRE |
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