Process Development of a Diacyl Glycerolacyltransferase-1 Inhibitor

Autor:	Seble Wagaw, Andrew S. Judd, Jianzhang Mei, Kenneth M. Engstrom, Andrew J. Souers, Gang Zhao, Brian J. Kotecki, Philip R. Kym, Matthew M. Ravn
Rok vydání:	2010
Předmět:	Diketone Chemistry Stereochemistry Process development Organic Chemistry Epimer Favorskii reaction Aryl ketone Physical and Theoretical Chemistry
Zdroj:	Organic Process Research & Development. 14:417-424
ISSN:	1520-586X 1083-6160
DOI:	10.1021/op900310v
Popis:	A synthesis of a selective diacyl glycerolacyltransferase-1 (DGAT-1) inhibitor, 1, is described. The synthesis illustrates a diketone Favorskii reaction on 9 in place of the more common ketoester variant for generation of the dicarboxycyclopentane core, the development of an efficient classical resolution of a key cyclopentyl ketoacid intermediate 4, and an ambient temperature Suzuki−Miyaura coupling which avoids epimerization of the labile aryl ketone of 1.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::dde9159c7cd78e997230e4074fbe58d4 https://doi.org/10.1021/op900310v Zobrazit plný text záznamu