Cadmium Toxicity and Liver Mitochondria
| Autor: | Takenobu Kamada, Yutaka Kishida, Motoaki Shichiri, Fumihide Ishibashi, Fujiya Furuyama, Norio Hayashi, Nobuhiro Sato, Bunji Hagihara, Takakatsu Matsumura, Hiroshi Abe, Toshihiko Suematsu |
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| Rok vydání: | 1978 |
| Předmět: |
Cadmium
medicine.medical_specialty Ethionine chemistry.chemical_element General Medicine Mitochondrion Cadmium chloride medicine.disease Biochemistry Cadmium poisoning Toxicology chemistry.chemical_compound Endocrinology chemistry Oral administration Internal medicine Respiration medicine Respiratory system Molecular Biology |
| Zdroj: | The Journal of Biochemistry. 84:117-125 |
| ISSN: | 1756-2651 0021-924X |
| DOI: | 10.1093/oxfordjournals.jbchem.a132100 |
| Popis: | The changes in liver mitochondrial respiratory activities and cytochrome concentrations were investigated when cadmium chloride was administered orally to adult, young, and ethionine-fed rats. Following a seven-day administration of 30 ppm cadmium in drinking water, adult rats showed no change, while young rats and ethionine-fed rats exhibited a marked increase in mitochondrial respiration with concomitant decrease of respiratory control index and P/O ratio. The concentrations of cytochromes aa3, b, and c + c1 in liver mitochondria were unchanged in adult rats, but increased significantly in ethionine-fed rats. In young rats receiving cadmium the liver mitochondrial protein increased with a slight change in the cytochrome concentration in mitochondria. It was further found that in adult rats a higher concentration (300 ppm) of cadmium in drinking water was toxic to the liver mitochondrial functions. Thus, the effect of oral administration of cadmium on the liver mitochondrial function depends on the condition of the animals. |
| Databáze: | OpenAIRE |
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