Antiviral 9-[2-(phosphonomethoxy)alkoxy]purines
| Autor: | D. M. Duckworth, D. N. Planterose, M. R. Harnden, R. M. Perkins |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
0301 basic medicine
Purine biology Stereochemistry Visna virus viruses 030106 microbiology Substituent Biological activity General Medicine biology.organism_classification 01 natural sciences Phosphonate Chemical synthesis 0104 chemical sciences 010404 medicinal & biomolecular chemistry 03 medical and health sciences chemistry.chemical_compound chemistry Alkoxy group Purine metabolism |
| Zdroj: | Antiviral Chemistry and Chemotherapy. 2:229-241 |
| ISSN: | 2040-2066 |
| Popis: | 9-[2-(Phosphonomethoxy)alkoxy]purines have been prepared and evaluated as antiviral agents. These compounds are the first reported acyclonucleotides in which an acyclic phosphonic acid-bearing substituent is attached to N-9 of a purine via a nitrogen-oxygen bond. Some 2-(phosphonomethoxy)ethoxy derivatives, e.g. (24), (25) and (27), have potent activity against herpesviruses. Some 3-hydroxy-2-(phosphonomethoxy)propoxy derivatives, e.g. (23) and (34), and a cyclic phosphonate (35), are potent and selective inhibitors of the replication of visna virus, a retrovirus. |
| Databáze: | OpenAIRE |
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