Investigation of properties and structural characterization of the quercetin inclusion complex with (2-hydroxypropyl)-β-cyclodextrin

Autor: Vesna Nikolić, Ivan M. Savic, Jelena Mladenović, Ljubiša Nikolić, Ivana Savic-Gajic, Blaga Radovanovic
Rok vydání: 2015
Předmět:
Zdroj: Journal of Inclusion Phenomena and Macrocyclic Chemistry. 82:383-394
ISSN: 1573-1111
1388-3127
DOI: 10.1007/s10847-015-0500-4
Popis: Quercetin is a typical plant flavonoid with a wide variety of pharmacological activities, including anti-inflammatory, anti-oxidative, anti-cancer and anti-age activity. It can be used for treatment of cardiovascular disorders. However, the application of quercetin in pharmacy is limited because of its poor aqueous solubility, low bioavailability, low permeability and instability. In order to overcome the mentioned limitations, an inclusion complex of quercetin with (2-hydroxypropyl)-β-cyclodextrin in a molar ratio of 1:1 have been prepared at room temperature by co-precipitation from ethanol solution. The inclusion complex was prepared at room temperature for 24 h by the co-precipitation method from ethanol solution. The obtained complex were evaporated and dried before the structural characterization. Based on the obtained results of FT-IR, DSC, 1H-NMR and XRD analysis, it can be concluded that the inclusion complex was formed by establishing the interaction between quercetin and (2-hydroxypropyl)-β-cyclodextrin. The phase solubility study indicates that the complexation of quercetin leads to increase the solubility of quercetin in water about 129-fold in the aqueous solution of HP-β-CD (10 mmol dm−3). Also, the photostability of quercetin was improved after its complexation with this cyclodextrin.
Databáze: OpenAIRE