Delayed effects of neutron radiation on human serum
| Autor: | Anna Michnik, Kinga Polaczek-Grelik, Ewa Sadowska-Krępa, Marta Staś, Joanna Gibińska, Zofia Drzazga |
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| Rok vydání: | 2016 |
| Předmět: |
Chromatography
Chemistry Analytical chemistry 02 engineering and technology Neutron radiation 021001 nanoscience & nanotechnology Condensed Matter Physics Serum samples 01 natural sciences 010406 physical chemistry 0104 chemical sciences Differential scanning calorimetry Blood serum Denaturation (biochemistry) Irradiation Physical and Theoretical Chemistry 0210 nano-technology |
| Zdroj: | Journal of Thermal Analysis and Calorimetry. 126:37-45 |
| ISSN: | 1588-2926 1388-6150 |
| DOI: | 10.1007/s10973-016-5255-7 |
| Popis: | Differential scanning calorimetry (DSC) provides a unique temperature-induced denaturation profile of the mixture of component proteins in the serum. This profile depends on a health status of serum donor, physicochemical properties of serum solution samples, and many experimental factors. Whether an exposure of serum sample to neutron radiation leads to changes in serum DSC profile has been checked in this study. The results indicate that immediately after the experiment, the differences between DSC serum profiles for irradiated and control samples are not significant. However, the distinct differences in the thermal unfolding of proteins present in the irradiated and control serum have been observed after 2 or 3 weeks of the storage of serum samples at about 4 °C. These differences have been found more pronounced at the dose of 5 Gy than at 0.5 Gy. |
| Databáze: | OpenAIRE |
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