| Autor: |
Ayoola Odeyemi, Adeola O. Ajibare, Olalekan E. Ojo, Oluwafemi T. Ojo, Boma Paul-Odo, Oluyomi O. Okunola, Fatiu A. Arogundade, Abubakr A. Sanusi |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Journal of Advances in Medicine and Medical Research. :247-254 |
| ISSN: |
2456-8899 |
| DOI: |
10.9734/jammr/2022/v34i2231600 |
| Popis: |
Introduction: Sickle cell disease (SCD) is a common cause of Chronic kidney disease (CKD) and microalbuminuria is a predictor of CKD. Aims: To determine the prevalence of microalbuminuria (MA) in SCD patients as well as the clinical correlates of MA in these individuals. Study Design: A hospital-based cross-sectional study. Place and Duration of Study: Obafemi Awolowo University Teaching Hospital, Ile-Ife, Osun State and Federal Medical Centre, Owo, Ondo State, between May 2016 to April 2017 Methodology: This cross-sectional study involved a total of 100 individuals with SCD. Blood and urine samples were obtained for haematology, chemistry and urine albumin/ creatinine ratio (UACR). Results: All the 100 studied subjects completed the study. The SCD group comprises both HbSS (86%) and HbSC (14%) subjects. The percentage of individuals with MA in the SCD subjects was 61%. The mean age of individuals with MA was 30.5(11.3) years compared to mean age of 25.3(6.8) years in those without MA (p= 0.012). In SCD subjects with microalbuminuria, eGFR was found to be significantly lower (p=0.044). The reticulocyte index, serum aspartate aminotransferase and serum albumin are the clinical correlates associated with MA in individuals with SCD. Conclusions: MA is prevalent among subjects with SCD and should be a routine method of detecting early onset of sickle cell nephropathy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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