Tamoxifen Has Little Effect on Cyclo-Oxygenase but Can Inhibit 5-Lipoxygenase
| Autor: | I. F. Stamford, I A Tavares, S. Morgan, P B Melhuish, Alan Bennett, J. A. Brown, Nicola Mascolo |
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| Rok vydání: | 1987 |
| Předmět: |
biology
business.industry medicine.medical_treatment Period (gene) medicine.disease chemistry.chemical_compound Breast cancer chemistry Arachidonate 5-lipoxygenase biology.protein medicine Cancer research Arachidonic acid Cyclo-oxygenase skin and connective tissue diseases business Receptor Adjuvant Tamoxifen medicine.drug |
| Zdroj: | Proceedings in Life Sciences ISBN: 9783642719066 |
| Popis: | The anti-oestrogen tamoxifen increases the survival of breast cancer patients by 20% over a 6-year period (Nolvadex adjuvant trial organization, 1985). Although tamoxifen is thought to act via oestrogen receptors, some patients with oestrogen-receptor-negative mammary carcinomas have also responded, indicating that other mechanisms may be involved. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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