The role of oximes in the management of acute poisoning with cholinesterase inhibitors pesticides: Case reports
| Autor: | Bilel Chefirat, Sameh Benzerga, Anissa Zergui, Haciba Rezk-kallah |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Pralidoxime biology business.industry Health Toxicology and Mutagenesis 010401 analytical chemistry Carbamate poisoning Acute intoxication Pesticide Toxicology University hospital 01 natural sciences Acute toxicity 0104 chemical sciences 03 medical and health sciences 0302 clinical medicine biology.protein Medicine 030216 legal & forensic medicine business Intensive care medicine Cholinesterase medicine.drug |
| Zdroj: | Toxicologie Analytique et Clinique. 33:101-107 |
| ISSN: | 2352-0078 |
| DOI: | 10.1016/j.toxac.2020.09.077 |
| Popis: | Summary Introduction Acute pesticides poisonings is a serious public health problem in Algeria. The indication of oximes in the treatment of poisoning by cholinesterase inhibitors pesticides is still controversial in practice, although it seems theoretically interesting because of the reversibility of the toxic-cholinesterase binding and the atropine-like effect. The interest of oximes in the management of cholinesterase inhibitors pesticides poisoning will be discussed through the study of the observation of 4 patients received at University Hospital Center of Oran (Algeria). Observations and discussion The study of the 4 observations enabled us to highlight the following points. For collapsed cholinesterase activity levels, it is better to administrate the highest recommended doses of Pralidoxime immediately, this will allow a rapid regeneration of an important fraction of inhibited cholinesterase activity, process which is concentration-dependent. Early intake of Pralidoxime with continuous injections appeared to have resulted in a rapid and favourable evolution. The use of oximes in carbamate poisoning is still debatable and needs further research. Conclusion In view of the data presented, oximes retain their place in the treatment of acute intoxication with cholinesterase inhibitors. Their indication should be discussed for each case taking into account the anamnesis, clinical presentation and level of cholinesterase activity. |
| Databáze: | OpenAIRE |
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