Distribution of Methamphetamine in the Cochlea
| Autor: | Hiromitsu Saito, Masahiro Mukaida, Sotaro Funasaka, Shigeyo Nagase, Fumihisa Hiraide |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Pathology
medicine.medical_specialty business.industry Anatomy Methamphetamine medicine.anatomical_structure Otorhinolaryngology Organ of Corti Spiral ligament otorhinolaryngologic diseases medicine Catecholaminergic cell groups Inner ear sense organs business Free nerve ending Spiral ganglion Cochlea medicine.drug |
| Zdroj: | Practica Oto-Rhino-Laryngologica. 84:1167-1172 |
| ISSN: | 1884-4545 0032-6313 |
| DOI: | 10.5631/jibirin.84.1167 |
| Popis: | Methamphetamine activates catecholaminergic neurons and releases noradrenalin from their nerve endings in the central nervous system. Many reports have described the distribution of methamphetamine in the central nervous system after systemic administration. However, there have been only a few studies on the effect of this drug on peripheral organs, and known dealing with the inner ear.The authors used immunohistochemical methods to investigate the effect of methamphetamine on the pheripheral auditory system. Methamphetamine was administered to guinea pigs via intraperitoneal injection. The distribution of methamphetamine in the cochlea was studied by light microscopy following its immunohistochemical staining, and the methamphetamine concentration in the serum was also measured.1. Histochemical examination revealed that methamphetamine was present in the hair cells of the organ of Corti, spiral ligament and spiral ganglion cells 30 minutes after administration.2. The drug concentration in the serum rose rapidly, and then dropped in a logarithmic way with time until it became nearly horinzontal after 6 hours.The results suggest that methamphetamine penetrated the blood-labyrinth barrier (BLB) and then reached the organ of Corti, although some methamphetamine took a route to the inner ear via the cerebrospinal fluid. The pharmacological effect of methamphetamine on the cochlea was excitation of the sensory cells, the afferent nerve fibers connecting to them, and the spiral ganglion cells. |
| Databáze: | OpenAIRE |
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