Synthesis of dendritic bisphosphonates as bone targeting ligands

Autor:	Kenta Ueda, Go Hirai, Hiroshi Suemune, Kazuma Shimoda, Mariko Aso, Takahiro Mitsuoka
Rok vydání:	2018
Předmět:	Bone mineral 010405 organic chemistry Chemistry Ligand medicine.medical_treatment Organic Chemistry Bisphosphonate 010402 general chemistry 01 natural sciences Biochemistry 0104 chemical sciences Bone targeting Drug Discovery medicine Biophysics Conjugate Quaternary carbon
Zdroj:	Tetrahedron Letters. 59:4528-4531
ISSN:	0040-4039
Popis:	A dendritic bisphosphonate carrying three bisphosphonate (BP) units in close proximity was designed as a ligand to conjugate large therapeutic molecules for their bone selective delivery. The Bu3P-catalyzed conjugate addition of nitromethane to vinylidene bisphosphonate was effective to construct a quaternary carbon center carrying BP units. Owing to multivalent interactions, the dendritic bisphosphonate showed considerable affinity for the bone mineral hydroxyapatite even in the presence of a competitor, demonstrating potential as a bone targeting ligand.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::dda1c1a6a1305cd8d2a6c8e52d74fb3c https://doi.org/10.1016/j.tetlet.2018.11.028 Zobrazit plný text záznamu Full Text from ScienceDirect