PHYTOCHEMICAL SCREENING AND INVITRO EVALUATION OF WOUND HEALING ACTIVITY, POLYHERBAL PREPARATION USING CHICK EMBRYO MODEL
| Autor: | null K. Sudheer Kumar, null D. Jeslin, null Segu Prathyusha, null Uttam Prasad Panigrahy, null Sabeena Hussain Syed, null JeetendraKumar Gupta |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Journal of Pharmaceutical Negative Results. :2110-2122 |
| ISSN: | 2229-7723 0976-9234 |
| Popis: | Reportedly, plants such as Cassia angustifolia and Tridax procumbens are used in Siddha medical systems to treat various diseases. Using a chick embryo wound model developed as part of the study, the presented research aimed to determine the wound-healing efficacy of methanol and aqueous extracts of the flowers and leaves. The experimental results show that the methanol extract exhibited good dose-dependent curative efficacy. In the chick embryo chorioallantoic membrane excision wound model, the 300g concentration of polyherbal methanol extract increased wound concentration by 50% compared to the negative control model. Compared to single plants and control groups, the results of the polyherbal Preparation were positive. The extract was also a reliable alternative to animal models for the preliminary screening compounds with wound-healing potential. |
| Databáze: | OpenAIRE |
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