A diet supplemented with n-3 polyunsaturated fatty acids influences the metabomscic and endocrine response of rabbit does and their offspring1
| Autor: | Jorge Lopez-Tello, Antonio Gonzalez-Bulnes, Maria Arias-Alvarez, Nora Formoso-Rafferty, P. G. Rebollar, Pedro Lorenzo, Pilar Millán, Rosa M. Garcia-Garcia, M. Rodríguez |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Offspring Biology 03 medical and health sciences chemistry.chemical_compound Internal medicine Lactation Genetics medicine 2. Zero hunger chemistry.chemical_classification Pregnancy Fetus medicine.diagnostic_test Cholesterol 0402 animal and dairy science 04 agricultural and veterinary sciences General Medicine medicine.disease 040201 dairy & animal science 030104 developmental biology Endocrinology medicine.anatomical_structure chemistry Animal Science and Zoology Lipid profile Food Science Lipoprotein Polyunsaturated fatty acid |
| Zdroj: | Journal of Animal Science. 95:2690-2700 |
| ISSN: | 1525-3163 0021-8812 |
| DOI: | 10.2527/jas.2017.1429 |
| Popis: | The aim of the present study was to evaluate the productive, endocrine, and metabolic responses as well as oxidative stress of rabbit does and their offspring when fed a diet supplemented with n -3 PUFA during their first productive cycle. To this aim, a total of 105 rabbit does were fed ad libitum from d 60 to 172 of age 2 isoenergetic and isoproteic diets dif - fering in fatty acid composition. The control diet ( n = 52 does) contained 45.9 g/kg of n -3 of the total fatty acids and the enriched diet ( n = 53 does) contained 149.2 g/kg of n -3 of the total fatty acids. Both experi - mental groups had similar feed intake during rearing, pregnancy, and lactation. The enrichment of diet had no effect on ultrasonographic assessment of does on d 9 and 16 of pregnancy, with an embryonic vesicle number and fetus and placenta size similar between groups ( P > 0.05). Even though there were no major effects ( P > 0.05) on fertility, duration of gestation, and number born alive and stillborn kits at parturition, live kits from enriched does were longer (71.6 ± 2.42 vs. 79.5 ± 2.13 mm; P 0.05). In enriched does, higher plasma leptin and estradiol concentrations than in control does ( P < 0.05) were observed. In addition, enriched females also had lower total and high-density lipoprotein cho - lesterol (HDL-c) than control females during lactation ( P < 0.05). Regarding offspring, the enrichment of diet with PUFA caused a hyperlipidemic status (greater values of plasma triglycerides, total cholesterol, and HDL-c; P < 0.05) at 1 d postpartum (dpp), compared with the control group, that disappeared at 32 dpp. Supplemented does before parturition and their off - spring at 1 dpp had greater oxidative stress than those in the control group. In conclusion, an increase of n -3 PUFA concentration in the diet of rabbit does and, consequently, of their offspring during a productive cycle alters their lipid profile and the indicators of oxi - dative stress, without major endocrine modifications or improvements in the productive variables. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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