Endocarditis por Aspergillus fumigatus en válvula nativa con hemocultivo positivo y galactomanano negativo. Descripción de un caso y revisión de la literatura
| Autor: | Carmen Pérez-Bellés, Rebeca Ortiz, Miguel Gobernado, Javier Pemán, Juan Frasquet, Emilia Cantón, Melitina Chirivella, Faisa Osseyran, Marisa Crespo, Anastasio Quesada |
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| Rok vydání: | 2007 |
| Předmět: |
Voriconazole
Native Valve Endocarditis biology business.industry medicine.medical_treatment medicine.disease Aspergillosis biology.organism_classification Microbiology Aspergillus fumigatus Infectious Diseases medicine.anatomical_structure Valve replacement Mitral valve medicine Endocarditis skin and connective tissue diseases business Fungemia medicine.drug |
| Zdroj: | Revista Iberoamericana de Micología. 24:157-160 |
| ISSN: | 1130-1406 |
| DOI: | 10.1016/s1130-1406(07)70034-7 |
| Popis: | Native valve endocarditis caused by Aspergillus spp. is an uncommon disease with a high mortality rate. Generally, Aspergillus is isolated from affected valve in post-mortem or biopsy specimens. However, its isolation from blood cultures is exceedingly rare. We report a case of fungal endocarditis in a native mitral valve with the isolation of Aspergillus fumigatus both in valve vegetation and in blood culture bottles. The patient underwent valve replacement and antifungal treatment with voriconazole and caspofungin, but he died on post-operative day 45 with disseminated aspergillosis confirmed by necropsy. Paradoxically, galactomannan antigen detection in serum was negative. This is the third case of Aspergillus endocarditis with positive blood culture reported in the literature. |
| Databáze: | OpenAIRE |
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