Determinants of Lung Bacterial Clearance in Mice after Acute Hypoxia1–3
| Autor: | Waldemar G. Johanson, Alan K. Pierce, Gary D. Harris |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Pulmonary and Respiratory Medicine
Lung Mucociliary clearance Klebsiella pneumoniae Phagocytosis Biology medicine.disease_cause biology.organism_classification Microbiology medicine.anatomical_structure Staphylococcus aureus Immunology Streptococcus pneumoniae Alveolar macrophage medicine Macrophage |
| Zdroj: | American Review of Respiratory Disease. 116:671-677 |
| ISSN: | 0003-0805 |
| Popis: | Net lung bacterial clearance in normal mice is determined by the balance of in vivo bacterial multiplication on the one hand, and the defense mechanisms of mucociliary clearance and phagocytosis and killing by the oxygen-dependent alveolar macrophage on the other. The bactericidal function of the macrophage is the major component of the defense mechanism. The effect of acute hypoxia on the defense mechanism was studied in mice exposed to aerosols of Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, and Streptococcus pneumoniae. Physical clearance was not impaired by acute hypoxia, and bacterial replication was not stimulated by the low oxygen atmosphere. Clearance of Staphylococcus aureus, Klebsiella pneumoniae, and Escherichia coli was impaired during acute hypoxia due to decreased phagocytosis or killing by the alveolar macrophage. The important human pathogen Streptococcus pneumoniae was cleared normally in the presence of acute hypoxia. This observation suggests that an oxygen-independen... |
| Databáze: | OpenAIRE |
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