Cause-Specific Mortality in Male US Veterans With Rheumatoid Arthritis
| Autor: | Harlan Sayles, Bryant R. England, Lisa A. Davis, Pascale Schwab, Kaleb Michaud, Grant W. Cannon, Brian C. Sauer, Andreas M. Reimold, Elizabeth Blair Solow, Ted R. Mikuls, Gail S. Kerr, Josh F. Baker, Liron Caplan |
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| Rok vydání: | 2015 |
| Předmět: |
030203 arthritis & rheumatology
education.field_of_study medicine.medical_specialty Proportional hazards model business.industry Mortality rate Population medicine.disease Comorbidity National Death Index Surgery 03 medical and health sciences 0302 clinical medicine Standardized mortality ratio Rheumatology Internal medicine Cohort medicine 030212 general & internal medicine education business Cause of death |
| Zdroj: | Arthritis Care & Research. 68:36-45 |
| ISSN: | 2151-464X |
| DOI: | 10.1002/acr.22642 |
| Popis: | Objective There has been limited investigation into cause-specific mortality and the associated risk factors in men with rheumatoid arthritis (RA). We investigated all-cause and cause-specific mortality in men with RA, examining determinants of survival. Methods Men from a longitudinal RA registry were followed from enrollment until death or through 2013. Vital status and cause of death were determined using the National Death Index. Crude mortality rates and standardized mortality ratios (SMRs) were calculated for all-cause, cardiovascular disease (CVD), cancer, and respiratory mortality. Associations with all-cause and cause-specific mortality were examined using multivariable Cox proportional hazards and competing-risks regression. Results There were 1,652 men with RA and 332 deaths. The leading causes of death were CVD (31.6%; SMR 1.77 [95% confidence interval (95% CI) 1.46–2.14]), cancer (22.9%; SMR 1.50 [95% CI 1.20–1.89]), and respiratory disease (15.1%; SMR 2.90 [95% CI 2.20–3.83]). Factors associated with all-cause mortality included older age, white race, smoking, low body weight, comorbidity, disease activity, and prednisone use. Rheumatoid factor concentration and nodules were associated with CVD mortality. There were no associations of methotrexate or biologic agent use with all-cause or cause-specific mortality. Conclusion Men in this RA cohort experienced increased all-cause and cause-specific mortality, with a 3-fold risk of respiratory-related deaths compared to age-matched men in the general population. Further studies are needed in order to examine whether interventions targeting potentially modifiable correlates of mortality might lead to improved long-term survival in men with RA. |
| Databáze: | OpenAIRE |
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