The homologous conjugate addition of thiols to electron-deficient cyclopropanes catalyzed by a calcium(II) complex

Autor:	Kristine A. Nolin, Caroline M. Braun, Alyssa M. Shema, Callie C. Dulin
Rok vydání:	2013
Předmět:	chemistry.chemical_classification chemistry Base (chemistry) Organic Chemistry Drug Discovery Thiol chemistry.chemical_element Electron Calcium Biochemistry Medicinal chemistry Catalysis Conjugate
Zdroj:	Tetrahedron Letters. 54:5889-5891
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2013.08.102
Popis:	The synthesis of γ-sulfanyl malonates was achieved through the addition of thiols to electron deficient cyclopropanes. These reactions are catalyzed by calcium acetylacetonate, Ca(acac) 2 . A variety of electron rich and electron deficient thiols were added without the need for prior activation or exogenous base. The thiol additions to donor–acceptor cyclopropanes bearing electron-rich and electron-deficient aromatic and heteroaromatic groups proceeded in good to excellent yields.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::dd78c4d9d0727fbf172bbcef5996475c https://doi.org/10.1016/j.tetlet.2013.08.102 Zobrazit plný text záznamu Full Text from ScienceDirect