Contribution to PNA-RNA Chimera Synthesis: One-Pot Microwave-Assisted Ugi Reaction to Obtain Dimeric Building Blocks

Autor: Karine Alvarez, Carine Baraguey, Clémence Mondielli, Reuben Ovadia, Jean-Jacques Vasseur
Rok vydání: 2016
Předmět:
Zdroj: European Journal of Organic Chemistry. 2017:469-475
ISSN: 1434-193X
DOI: 10.1002/ejoc.201601190
Popis: we report a solution phase synthesis to obtain dimeric PNA-RNA building blocks using a microwave-assisted Ugi four-component reaction. The mixture of a functionalized amine, a carboxymethyl nucleobase, paraformaldehyde and the N4, 2'-O, 3'-O-tribenzoyl-5'-deoxy-5'-isocyano-cytidine generates in one step the dimeric chimeras. This method is simple and provides a fast access (5 min) to diversity as exemplified.
Databáze: OpenAIRE
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