Prognostic molecular biomarkers for cutaneous malignant melanoma
| Autor: | Christine Kuo, Kazuo Koyanagi, Norihiko Narita, Ryo Tanaka, Dave S.B. Hoon |
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| Rok vydání: | 2011 |
| Předmět: |
Pathology
medicine.medical_specialty business.industry medicine.medical_treatment Melanoma General Medicine medicine.disease Targeted therapy medicine.anatomical_structure Circulating tumor cell Oncology microRNA medicine Cancer research Surgery Epigenetics Lymph business neoplasms Lymph node Epigenomics |
| Zdroj: | Journal of Surgical Oncology. 104:438-446 |
| ISSN: | 0022-4790 |
| DOI: | 10.1002/jso.21969 |
| Popis: | Molecular signatures of melanoma have propelled new approaches to early diagnosis, monitoring of treatment response, and targeted therapy. This review discusses messenger RNA (mRNA), genomic, and epigenomic melanoma biomarkers in blood and tissue specimens. The major focus is on tissue-based molecular assays to upstage sentinel lymph nodes (SLNs), and blood-based assays to detect melanoma progression by monitoring levels of circulating tumor cells (CTC) and circulating DNA. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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