Investigation of Four Cases of Stevens–Johnson Syndrome among Participants in a Mass Drug Administration Campaign with Sulfadoxine-Pyrimethamine and Primaquine in Haiti, 2020
| Autor: | Michelle A. Chang, Bernadette Fouché, Willy LaFortune, Kathleen Holmes, Jonas Rigodon, Stanley Juin, Samson Marseille, Eric Rogier, Michael Green, Taba Kheradmand, Samuel G. Moore, David A. Gaul, Jacques Boncy, Marc-Aurele Telfort |
|---|---|
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | The American Journal of Tropical Medicine and Hygiene. |
| ISSN: | 1476-1645 0002-9637 |
| Popis: | In 2018, a mass drug administration (MDA) campaign for malaria elimination was piloted in Haiti. The pilot treated 36,338 people with sulfadoxine-pyrimethamine (SP) and primaquine; no severe adverse events were detected. In 2020, another MDA campaign using the same medications was implemented to mitigate an upsurge in malaria cases during the COVID-19 pandemic. Four cases of Stevens–Johnson syndrome (SJS) were identified among the 42,249 people who took the medications. Three of these individuals required hospitalization; all survived. In addition to SP ingestion, an investigation of potential causes for increased SJS cases identified that all four cases had human leukocyte antigens A*29 and/or B*44:03, another known risk factor for SJS. Additionally, three of the four case individuals had antibodies to SARS-CoV-2, and the fourth may have been exposed around the same time. These findings raise the possibility that recent SARS-CoV-2 infection may have contributed to the increased risk for SJS associated with SP exposure during the 2020 campaign. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|