Metabolism of Terbufos in Rat Liver

Autor: Xian-Lin Du, Jin-Tong Li, Shi-Jie Sheng
Rok vydání: 1999
Předmět:
Zdroj: Journal of Occupational Health. 41:62-68
ISSN: 1348-9585
1341-9145
Popis: Metabolism of Terbufos in Rat Liver: Jin- Tong LI, et al. Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing, China, 100850—Biotransformation of terbufos in rat liver revealed four metabolites in the effluent prepared with a C 18 cartridge after the rat liver was perfused for one hour in situ. Analysing the spectrogram of GC-IR and GC-MS, metabolite IV appeared to be an oxidative desulfuration product of terbufos with the formula C 9 H 21 O 3 PS 2 , the recovery of which in the effluent was 2.13%; metabolite I appeared to be an hydrolysate of metabolite IV with the formula C 5 H 13 O 3 PS, the recovery of which was 0.13%; metabolite II appeared to be an hydrolysate of terbufos with the formula C 5 H 13 O 2 PS 2 , the recovery of which was 2.65%; metabolite III appeared to be a methylate of metabolite II, with the formula C 6 H 15 O 2 PS 2 , the recovery of which was 1.42%. Relatively the recovery of terbufos was 40.8%. These results were in accord with the regular metabolic pattern in vivo of phosphorothioates with a thioether group. (J Occup Health 1999; 41: 62-68)
Databáze: OpenAIRE
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