Severe vitamin D deficiency upon admission in critically ill patients is related to acute kidney injury and a poor prognosis
| Autor: | A. Zapatero, J. Nolla, Purificación Pérez-Terán, Joan R. Masclans, C. Climent, Irene Dot, Yolanda Diaz, M.P. Gracia |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Poor prognosis Critically ill business.industry Acute kidney injury 030208 emergency & critical care medicine University hospital medicine.disease Intensive care unit vitamin D deficiency law.invention 03 medical and health sciences 0302 clinical medicine law Internal medicine medicine Vitamin D and neurology 030212 general & internal medicine business Area under the roc curve |
| Zdroj: | Medicina Intensiva (English Edition). 42:216-224 |
| ISSN: | 2173-5727 |
| DOI: | 10.1016/j.medine.2017.07.002 |
| Popis: | Objectives To evaluate the prevalence of vitamin D deficiency in critically ill patients upon admission to an Intensive Care Unit (ICU) and its prognostic implications. Design A single-center, prospective observational study was carried out from January to November 2015. Patients were followed-up on until death or hospital discharge. Setting The department of Critical Care Medicine of a university hospital. Patients All adults admitted to the ICU during the study period, without known factors capable of altering serum 25(OH)D concentration. Interventions Determination of serum 25(OH)D levels within the first 24 h following admission to the ICU. Main variables of interest Prevalence and mortality at 28 days. Results The study included 135 patients, of which 74% presented deficient serum 25(OH)D levels upon admission to the ICU. Non-survivors showed significantly lower levels than survivors (8.14 ng/ml [6.17–11.53] vs. 12 ng/ml [7.1–20.30]; p = .04), and the serum 25(OH)D levels were independently associated to mortality (OR 2.86; 95% CI 1.05–7.86; p = .04). The area under the ROC curve was 0.61 (95% CI 0.51–0.75), and the best cut-off point for predicting mortality was 10.9 ng/ml. Patients with serum 25(OH)D Conclusion Vitamin D deficiency is highly prevalent upon admission to the ICU. Severe Vitamin D deficiency (25[OH]D |
| Databáze: | OpenAIRE |
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