| Popis: |
For several years we have been analysing the sequences of P-type ion pumps in order to obtain structural information to provide a basis for understanding the mechanism of their action. There are now over one hundred sequences in the data banks, about half of which are for sodium or calcium pumps. From a study of the location of conserved and variable regions, combined with secondary structure prediction and the use of information from chemical modification and site directed mutagenesis, we have put forward a model for the Ca2+ -pump (1), which, although it cannot be claimed to be definitive, is consistent with almost all of the extensive experimental results. |
