Distinguishing isobaric amino acids in sequence analysis of cyclosporins by fast atom bombardment and linked-scan mass spectrometry

Autor:	Miroslav Ryska, Vladimír Havlíček, Winfried Wagner-Redeker, Petr Sedmera, Alexandr Jegorov
Rok vydání:	1995
Předmět:	Cyclosporins chemistry.chemical_classification Chemistry Sequence analysis Stereochemistry Mass spectrum Analytical chemistry Isobaric process Fast atom bombardment Mass spectrometry Spectroscopy Ion Amino acid
Zdroj:	Journal of Mass Spectrometry. 30:940-948
ISSN:	1096-9888 1076-5174
Popis:	An analytical protocol suggested previously for the mass spectrometric sequence analysis of cyclosporins was extended by addition of methods for discrimination among isobaric amino acids differing either in the nature of the side-chain or N-substitution. The former goal was achieved by comparison of B/E linked-scan mass spectra of corresponding collisionally activated immonium ions with those of standard amino acids and the latter by comparison of B/E fragment ion spectra of [M + H]+ and [Md + 2H]+ ions. The use of the improved protocol is illustrated by the structure elucidation of a novel natural cyclosporin, [Leu9]CS.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::dd6b40efd574b52004959e4840e28cf2 https://doi.org/10.1002/jms.1190300703 Zobrazit plný text záznamu Plný text