Steroid-induced diabetes: a clinical and molecular approach to understanding and treatment
| Autor: | Roy E. Weiss, Jessica L. Hwang |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Autoimmune disease
business.industry Endocrinology Diabetes and Metabolism Insulin medicine.medical_treatment medicine.disease Pathogenesis Endocrinology Insulin resistance Glucocorticoid therapy Diabetes mellitus Immunology Internal Medicine medicine Steroid-induced diabetes Solid organ transplantation business |
| Zdroj: | Diabetes/Metabolism Research and Reviews. 30:96-102 |
| ISSN: | 1520-7552 |
| DOI: | 10.1002/dmrr.2486 |
| Popis: | Since the advent of glucocorticoid therapy for autoimmune disease in the 1940s, their widespread application has led to the concurrent therapy-limiting discovery of many adverse metabolic side effects. Unanticipated hyperglycemia associated with the initiation of glucocorticoids often leads to preventable hospital admissions, prolonged hospital stays, increased risks for infection and reduced graft function in solid organ transplant recipients. Challenges in managing steroid-induced diabetes stem from wide fluctuations in post-prandial hyperglycemia and the lack of clearly defined treatment protocols. The mainstay of treatment is insulin therapy coincident with meals. This article aims to review the pathogenesis, risk factors, diagnosis and treatment principles unique to steroid-induced diabetes. |
| Databáze: | OpenAIRE |
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