Synthesis and antifungal activity of some carbamate-containing azaheterocycles

Autor:	V. B. Kovalev, O. V. Degtyarev, O. L. Titova, A. V. Velikorodov
Rok vydání:	2011
Předmět:	Pharmacology Indole test Carbamate biology Chemistry Stereochemistry medicine.medical_treatment Trichophyton rubrum biology.organism_classification Tautomer In vitro chemistry.chemical_compound Drug Discovery medicine Organic chemistry Microsporum canis Isoxazole Candida albicans
Zdroj:	Pharmaceutical Chemistry Journal. 44:536-539
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-011-0513-2
Popis:	A series of carbamate-containing derivatives of 1,2- and 1,4-oxazine, isoxazoline, isoxazole, benzimidazole-3-oxide, and indole were obtained by [3 + 2]-cycloaddition and ring-closure reactions. The antifungal activity of the synthesized compounds was studied in vitro against Microsporum canis, Trichophyton rubrum, and Candida albicans. Among the tested compounds, the maximum antifungal activity was observed for tautomeric 5(6)-alkoxycarboxamido derivatives of 2-aryl-1-hydroxybenzimidazole-3-oxide sodium salts and 1,2-oxazines.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::dd6863f2e7ad22df6a91d8641b056b22 https://doi.org/10.1007/s11094-011-0513-2 Zobrazit plný text záznamu Plný text ve formátu PDF