Bone density in youth with prediabetes: results from the National Health and Nutrition Examination Survey, 2005–2006

Autor: Y Ishikawa, X Chen, S Gallo, Joseph M. Kindler, D Zhan, E L P Sattler
Rok vydání: 2021
Předmět:
Zdroj: Osteoporosis International. 33:467-474
ISSN: 1433-2965
0937-941X
DOI: 10.1007/s00198-021-06148-2
Popis: Youth with type 2 diabetes might have suboptimal peak bone mass, but it is unknown whether similar effects are evident in youth with prediabetes. Results from this study suggest that diabetes-related effects on peak bone mass likely occur before disease onset, and involve the muscle-bone unit. Type 2 diabetes might adversely influence bone health around the age of peak bone mass, but it is unknown whether diabetes-related effects on areal bone mineral density (aBMD) are evident in youth with prediabetes. We compared age-related trends in aBMD and associations between lean body mass (LBM) and aBMD between children and adolescents with prediabetes vs. normal glucose regulation. Cross-sectional analysis of data from the National Health and Nutrition Examination Survey (2005–2006) in youth ages 12–20 years (49% female, 34% black) with prediabetes (n = 267) and normal glucose regulation (n = 1664). Whole body aBMD and LBM were assessed via DXA. LBM index (LBMI) and Z-scores for aBMD and LBMI were computed. Unadjusted between-group comparisons revealed greater mean weight and LBMI Z-scores in youth with prediabetes vs. normal glucose regulation, but similar bone Z-scores between the two groups. While accounting for differences in BMI Z-score, there was a significant interaction between prediabetes status and age with respect to whole body aBMD Z-score (P
Databáze: OpenAIRE
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