Neuropharmacological Studies on Ethanol Extracts ofValeriana officinalisL.: Behavioural and Anticonvulsant Properties

Autor:	K.-O. Hiller, G. Zetler
Rok vydání:	1996
Předmět:	Pharmacology Valeriana officinalis Ethanol medicine.medical_treatment Pharmacognosy Valerenic acid chemistry.chemical_compound Anticonvulsant chemistry medicine Haloperidol Diazepam medicine.drug Picrotoxin
Zdroj:	Phytotherapy Research. 10:145-151
ISSN:	1099-1573 0951-418X
Popis:	An ethanol total extract of the roots of Valeriana officinalis L. in doses equivalent to 0.5–800 mg valerian root/kg b.w.i.p. was tested in male mice for possible neuropharmacological efficacy and in this respect compared with diazepam and haloperidol. The extract did not modify spontaneous motility, nociception or body temperature, and did not produce palpebral ptosis. However, it was anticonvulsant against picrotoxin (but not pentetrazol and harman) with an ED50 between 4.5 and 6 mg/kg and it prolonged thiopental anaesthesia. After fractionation of the crude extract, the antipicrotoxin activity was present mainly in the methylene chloride fraction (ED50=0.25 mg/kg). Pure valerenic acid (12.5 mg/kg b.w.i.p.) also exerted an antipicrotoxin effect.
Databáze:	OpenAIRE
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