Human leukocyte antigen distribution and genomic ancestry in Brazilian patients with sickle cell disease

Autor:	M.C.L. Martins, E. M. F. L. Domingues, F. C. B. de Souza, Eduardo Tarazona-Santos, V. R. Souza, P. S. Rodrigues, M. C. F. da Silva-Malta, Luciana W. Zuccherato
Rok vydání:	2017
Předmět:	0301 basic medicine medicine.medical_treatment Immunology Cell Genetic admixture Hematopoietic stem cell transplantation Disease Human leukocyte antigen Biology Transplantation 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure hemic and lymphatic diseases Genetics medicine Immunology and Allergy Distribution (pharmacology) Allele 030215 immunology
Zdroj:	HLA. 90:211-218
ISSN:	2059-2302
DOI:	10.1111/tan.13102
Popis:	Hematopoietic stem-cell transplantation (HSCT) is currently the only established curative treatment for sickle cell disease (SCD), but is limited by donor availability. Ethnicity is thought to have an impact on the complications experienced by patients that undergo HSCT and on the likelihood of identifying an HLA matched donor. In the present study, we investigated the genomic ancestry and the distribution of HLA allele groups in Brazilian patients with SCD, compared these HLA profiles to worldwide populations and evaluate the availability of HLA-matched donors. A broad intercontinental admixture of patients with SCD was observed, with African ancestry ranging from 6.7% to 93.4%. In a dendrogram based on HLA frequencies, Brazilian patients with SCD were included in a branch containing only populations with a significant African component. Among the 126 patients evaluated, 10 (8%) found a HLA-matched unrelated donor in a database of 18134 donors. Self-reported white, brown and black matched donors were identified, and no significant difference in the percentage of compatible donors was observed between these ethnic groups. Our results show that Brazilian patients with SCD are very admixed, indicating that this group is a promising target for admixture mapping of genes involved in complications after HSCT. Additional studies may help to clarify the impact of the genetic diversity and admixture of these patients on the donor availability.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::dd566ad1f3a7d2c18d1d6c8293f4f1ee https://doi.org/10.1111/tan.13102 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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