Synthesis and post-coital contraceptive activity of a new series of substituted 2,3-diaryl-2H-1-benzopyrans

Autor:	K. Hajela, R. S. Kapil
Rok vydání:	1997
Předmět:	Pharmacology Organic Chemistry General Medicine Dose level Chemical synthesis Compound 32 Benzopyran chemistry.chemical_compound Route of administration chemistry Drug Discovery Benzene derivatives Benzopyrans Ovum implantation
Zdroj:	European Journal of Medicinal Chemistry. 32:135-142
ISSN:	0223-5234
DOI:	10.1016/s0223-5234(97)87540-x
Popis:	Summary A series of substituted 2,3-diaryl-2H-1-benzopyrans have been synthesized and screened for their post-coital contraceptive activity in rats. Most of the compounds showed 100% inhibition in a single day schedule at a dose level of 1.0 mg/kg. Compound 32 was found to be the most active with a minimum effective dose (MED) of 0.2 mg/kg in single day testing. Further, it also showed high antiestrogenic activity and is devoid of any agonistic activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::dd42e6632fa0e20545aa673477821d3d https://doi.org/10.1016/s0223-5234(97)87540-x Zobrazit plný text záznamu Full Text from ScienceDirect