| Autor: |
R. Guthoff, Markus Kleineidam, Hans-Peter Beck-Bornholdt, Frank Schiller, Lee C. Chumbley |
| Rok vydání: |
1993 |
| Předmět: |
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| Zdroj: |
International Journal of Radiation Oncology*Biology*Physics. 25:277-281 |
| ISSN: |
0360-3016 |
| DOI: |
10.1016/0360-3016(93)90349-z |
| Popis: |
Purpose : The influence of the dose-rate on tumor response in radiotherapy with 106-Ruthenium eye plaques has been investigated in an erimental tumor system. Materials and Methods: The identical total dose was applied within three different overall treatment times (42 hr, 192 hr and 312 hr), corresponding to dose-rates of 6.0 Gy/hr, 1.3 Gy/hr and 0.8 Gy/hr. Results: The therapeutic outcome of brachytherapy varied significantly between the three groups of animals treated with different dose-rates. At a dose-rate of 1.3 Gy/hr all tumors were locally controlled, but no local control was observed when a dose-rate of 6.0 Gy/hr was delivered. 0.8 Gy/hr was less effective than 1.3 Gy/hr but more effective than 6.0 Gy/hr. Conclusion: These results were unexpected but they might be explained by an incomplete reoxygenation if the overall treatment time is too short (42 hr, dose-rate 6.0 Gy/hr) and by proliferation of tumor cells under treatment if the overall treatment time is too long (312 hr, 0.8 Gy/hr). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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