| Autor: | Frolov Va |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Inotrope
medicine.medical_specialty Chemistry Endoplasmic reticulum Antagonist chemistry.chemical_element General Medicine Calcium musculoskeletal system General Biochemistry Genetics and Molecular Biology law.invention Endocrinology Blood pressure Nifedipine law Internal medicine medicine Ultrastructure Electron microscope medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 134:221-222 |
| ISSN: | 0007-4888 |
| Popis: | Spontaneously hypertensive rats (SHR) with high systolic pressure received calcium antagonist nifedipine in medium therapeutic doses for 2 weeks. Electron microscopy of the myocardium revealed considerable changes in the sarcoplasmic reticulum manifested in dramatic dilation of tubules, destruction of membranes, and appearance of amorphous matter of medium electron density in tubules in animals treated with nifedipine. Since sarcoplasmic reticulum plays an important role in calcium-dependent excitation-contraction coupling, the observed structural changes can underlie the negative inotropic effect of long-term nifedipine therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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