The Insulin-Like Growth Factor System in Human Immunodeficiency Virus Infection: Relations to Immunological Parameters, Disease Progression, and Antiretroviral Therapy1
| Autor: | Stig S. Frøland, Dagfinn Ekse, P Aukrust, Jeffrey M P Holly, Per Eystein Lønning, Thor Ueland, S.I. Helle |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
Protease Nucleoside analogue Endocrinology Diabetes and Metabolism medicine.medical_treatment Biochemistry (medical) Clinical Biochemistry Biology biology.organism_classification medicine.disease Biochemistry Virology Endocrinology Acquired immunodeficiency syndrome (AIDS) Immunopathology Internal medicine Immunology medicine Viral disease medicine.symptom Sida Viral load Wasting medicine.drug |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 86:227-233 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem.86.1.7135 |
| Popis: | Endocrine dysfunctions have previously been reported in human immunodeficiency virus (HIV) infection. In this study we evaluated the relation of immunological parameters, virus load, clinical stage, and wasting to several parameters of the insulin-like growth factor (IGF) system in 76 patients with HIV infection, of whom 37 had developed acquired immune deficiency syndrome (AIDS). A subgroup of 26 untreated patients was followed during longitudinal testing, while the effects of antiretroviral therapy were evaluated in 34 patients (nucleoside analogs in 9, nucleoside analogs in combination with protease inhibitors in 25). Twenty healthy sex- and age-matched controls were analyzed for comparison. IGF-II was decreased (P = 0.03) and IGF-binding protein-2 (IGFBP-2) and IGFBP-3 protease activity were increased (P < 0.001) in AIDS patients compared with other HIV-infected individuals and controls. Plasma levels of IGFBP-2 and IGFBP-3 protease activity correlated positively to virus load (P < 0.001) and tumor ne... |
| Databáze: | OpenAIRE |
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