Sulfoxide-mediated diastereoselective Michael additions. New enantioselective synthesis of C-4 substituted 2-pyroaminoadipic acids

Autor:	Alfonso de Dios, Alicia Barrasa, Carlos Alvarez-Ibarra, Hassan Acherki
Rok vydání:	1999
Předmět:	chemistry.chemical_compound Scope (project management) chemistry Stereochemistry Organic Chemistry Drug Discovery Enantioselective synthesis Sulfoxide Biochemistry Asymmetric induction Conjugate
Zdroj:	Tetrahedron Letters. 40:5763-5766
ISSN:	0040-4039
Popis:	Diastereoselective reactions of suitably functionalized homochiral β-iminosulfoxides with Michael acceptors provide a new and efficient route for the asymmetric synthesis of C-4 substituted 2-pyroaminoadipates. Extension of the scope of the sulfoxide-mediated aza-enolate conjugate addition (Hua's reaction) has also been explored.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::dd2f794d5b8ab1e65bf676f972808141 https://doi.org/10.1016/s0040-4039(99)01047-3 Zobrazit plný text záznamu Full Text from ScienceDirect