Microwave assisted aminocatalyzed [3 + 2] annulation between α-iminonitriles and succinaldehyde: synthesis of pyrrole-3-methanols and related polycyclic ring systems

Autor:	Sachin Choudhary, Panduga Ramaraju, Nisar A. Mir, Deepika Singh, Indresh Kumar
Rok vydání:	2016
Předmět:	Annulation 010405 organic chemistry General Chemical Engineering General Chemistry 010402 general chemistry Ring (chemistry) 01 natural sciences Microwave assisted 0104 chemical sciences chemistry.chemical_compound Succinaldehyde chemistry Microwave irradiation Organic chemistry Pyrrole
Zdroj:	RSC Advances. 6:39741-39749
ISSN:	2046-2069
DOI:	10.1039/c6ra06831f
Popis:	A quick and highly efficient method for the synthesis of substituted pyrrole-3-methanols from α-iminonitriles and succinaldehyde under microwave irradiation is reported. This one-pot method involves aminocatalyzed direct Mannich reaction-cyclization-dehydrocyanation followed by NaBH4 reduction sequence in good yields (up to 75%). Further applications of this method are demonstrated through the rapid synthesis of polycyclic heterocycles such as pyrrolo-dihydrochromene and pyrrolo-dihydroquinoline compounds.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::dd2ce40577b3fe07a96fb368fee331f1 https://doi.org/10.1039/c6ra06831f Zobrazit plný text záznamu